Job Description

Sr. Scientist, Vector Biology

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Sr. Scientist, Vector Biology as part of the Vector Biology team based in Philadelphia, PA.

Role Overview

This role focuses on the design, construction, and testing of lentiviral vector (LVV) plasmids to support gene overexpression and knockout studies. The position involves generating engineered cell lines, producing small-scale LVVs, and conducting molecular and cellular assays to characterize vector function. The ideal candidate will work independently while collaborating closely with cross-functional teams in upstream, downstream, and analytical development.

Key Responsibilities

• Design and test various lentiviral vector plasmids and helper plasmids for LVV production
• Cloning and plasmid construction for gene over-expression and/or knock-out
• Manage internal plasmid construction and database being the liaison with researchers in plasmid/LVV designs
• Generate various cell lines such as KO or overexpression of single or multiple genes
• Small scale LVV production using suspension cell lines
• Conduct molecular and cellular assay for all aspects of LVV function & characterization
• Work independently in planning, performing, analyzing, reporting and presenting experimental data
• Closely working with upstream, downstream and analytical team in Vector bio.

Requirements

• PhD degree with minimum 3 years' experience in molecular biology, biochemistry, virology, or related field.
• Extensive experience in molecular biology techniques including cloning, Wester blotting, ddPCR, and gene editing
• Experience in multicolor flow cytometry and single cell cloning & cell sorting
• Able to adjust workload based upon priorities

The anticipated base pay range is: $123,605 - $162,232 USD.

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

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